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Action on Smoking and Health
A National Legal-Action Antismoking Organization Entirely Supported by Tax-Deductible Contributions
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Prenatal Environmental Tobacco Smoke Exposure Promotes Adult Atherogenesis and Mitochondrial Damage in Apolipoprotein E–/– Mice Fed a Chow Diet [12/15-1]
By
From the Division of Molecular and Cellular Pathology, Department of Pathology (Z.Y., C.A.K., K.V., S.W.B.), and Department of Environmental Health Sciences, School of Public Health (E.M.P.), University of Alabama at Birmingham; Department of Human Ecology, Division of Nutritional Sciences, University of Texas at Austin (M.M.M.); and School of Veterinary Medicine, Louisiana State University, Baton Rouge (A.P.).
Background— Environmental tobacco smoke (ETS) exposure is recognized as a cardiovascular disease risk factor; however, the impact of prenatal ETS exposure on adult atherogenesis has not been examined. We hypothesized that in utero ETS exposure promotes adult atherosclerotic lesion formation and mitochondrial damage.
Methods and Results— Atherosclerotic lesion formation, mitochondrial DNA damage, antioxidant activity, and oxidant load were determined in cardiovascular tissues from adult apolipoprotein E–/– mice exposed to either filtered air or ETS in utero and fed a standard chow diet (4.5% fat) from weaning until euthanasia. All parameters were significantly altered in male mice exposed in utero to ETS.
Conclusions— These data support the hypothesis that prenatal ETS exposure is sufficient to promote adult cardiovascular disease development.
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