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Action on Smoking and Health
A National Legal-Action Antismoking Organization Entirely Supported by Tax-Deductible Contributions
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New Study: Tobacco Smoking and Oral Clefts in Infants [08/04-1]
Excerpts from: Tobacco smoking and oral clefts: a meta-analysis.
By Little J, Cardy A, Munger RG. Department of Medicine and Therapeutics, University of Aberdeen, Foresterhill,
Scotland National Library of Medicine [04/16/04]
OBJECTIVE: To examine the association between maternal smoking and non-syndromic
orofacial clefts in infants.
METHODS: A meta-analysis of the association between
maternal smoking during pregnancy was carried out using data from 24
case-control and cohort studies.
FINDINGS: Consistent, moderate and
statistically significant associations were found between maternal smoking and
cleft lip, with or without cleft palate (relative risk 1.34, 95% confidence
interval 1.25-1.44) and between maternal smoking and cleft palate (relative risk
1.22, 95% confidence interval 1.10-1.35). There was evidence of a modest
dose-response effect for cleft lip with or without cleft palate.
CONCLUSION: The
evidence of an association between maternal tobacco smoking and orofacial clefts
is strong enough to justify its use in anti-smoking campaigns.
Click here to view a similar study: Smoking and Orofacial Clefts: A United Kingdom–Based
Case-Control Study
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